Recently a massive meta study showed what anyone watching already knew. It showed that people with type 2 diabetes are between 2 and 5 times as likely to have 24 of the 25 studied major types of cancer than the general population, a population which includes a large segment of type 2 diabetics.
Ballparked, the cancer incidence among type 2 diabetics is roughly 3.5 times as great as the cancer incidence among non-type 2 diabetics. That, my friends, is a smoking gun. If you want to develop cancer you should first try and develop type 2 diabetes. The rest should take care of itself.
Type 2 diabetes is largely the result of consuming volatile sugars along with proteins, flavonoids and opiates from foods like wheat. The pathways are pretty well nailed down. Sugar grows intestinal microorganisms. Opiates dull the immune system while, at the same time, mimicking the proteins displayed by the microorganisms. The immune system makes the intestinal walls porous. The partially digested opiates, sugars, flavonoids and proteins flow into the bloodstream, and wreck havoc all over the body.
Type 2 diabetes is characterized by insulin resistance. Opiates from wheat and other plant foods mimic insulin. They clog up insulin receptors, and prevent cells from consuming blood glucose. Cells starve. The blood increasingly fills with glucose, and elicits ever higher levels of insulin.
Cancer represents portions of the body ceasing their normal toil. Cells cease to consume food for the performance of specialized tasks, and instead consume food for the creation of useless tissue. Human cells perform this transformation when insulin resistance causes them to abandon their normal diet of glucose.
Cells are protected from assault by tissue transglutaminase (TTG), a protein in the extracellular matrix (ECM). Ingested flavonoids attack and destroy tissue transglutaminase, leaving cells unprotected. Unprotected cells, starved by insulin resistance, start importing and burning flavonoids for fuel. Unfortunately flavonoids do not lend themselves well to being burned for energy.
Glutamate is the most commonly consumed flavonoid. Glutamate is so essential to cancer transformation that many cancers produce their own glutamate. Wheat is roughly 1/4 glutamate.
PKM2 is a catalyst which tells cells why to burn fuel .....whether to burn it for energy or for the creation of tissue. As shown above type 2 diabetes fills the blood with glucose and makes cells starve for glucose. The glucose gradient across outer cell walls causes cells to redirect the aggregation of PKM2. The insulin-resistance form of PKM2 causes cells to start creating tissue.
Cells start creating randomly mutated tissue, combining human DNA with whatever proteins happen to be hanging around in the cytosol. From this point evolution takes over. In order to survive, mutated cells must feed themselves, reproduce, and avoid the body's immune system. Unsuccessful cancer cells die. Successful cancer cells survive and form tumors.
In a nutshell .....When human cells use fuel for energy, they use mitochondria to make ATP. Then they burn the ATP. When cancer cells use glucose to create tissue, they ferment it directly. The cancer transformation starts with human cells in a glucose-charged environment. Because of insulin resistance the human cells cannot use the glucose. The cancer transformation replaces human cells with cells which can use the glucose.
For avoiding cancer our challenge is to end the insulin resistance and the glucose buildup.