I, too, am having bone pain. Even though I have been off the Femara (same as Arimidex, Aromasin, Tomoxifen) for 3 weeks, I am still having pain. Has your wife tried percocet at night. That has been, so far, the only way I can sleep. Then, in the morning, I have to take an antiinflamatory med such as ibuprofen. Helps to some degree. Just had conversation with MD yesterday about this. One option if it gets really bad is a Duragesic patch with low dose pain medicine to even out peeks and valleys. So sorry she's experiencing this pain. Hope things get better.