How do lifestyle factors and exposure to environmental substances affect our cancer risk?
by yankmom on Thu Jun 21, 2012 04:20 AM
by siblingof on Thu Jun 21, 2012 12:23 PM
by yankmom on Thu Jun 21, 2012 03:05 PM
On Jun 21, 2012 12:23 PM siblingof wrote: According to wikipedia, it can spread to the lungs, liver or lymph nodes.
http://en.wikipedia.org/wiki/Gliosarcoma "" target="_blank" rel="nofollow">http://en.wikipedia.org/wiki/Gliosarcoma " target="_blank" rel="nofollow">http://en.wikipedia.org/wiki/Gliosarcoma
On Jun 21, 2012 12:23 PM siblingof wrote:
I read that on wikipedia before, but my daughter-in-law's oncologist told us that since it started in the brain that it would not go anywhere else. Now, she is having trouble with her lungs. One lung is 90% filled with fluid. They drained over 1,000 ccs off and didnt' even get half. They make comments that it could be infection, side affect of chemo or the cancer has spread. I was just wondering if could spread. The oncologist told us at the beginning at the cancer diagnosis that it wouldn't spread. I guess I am just looking for reassurance that it hasn't.
by siblingof on Thu Jun 21, 2012 05:38 PM
by GBMBGONE on Fri Jun 22, 2012 01:02 AM
Absolutely, Albeit rare it does happen in about 2% of cases. It appears that it is the sarcomatous aspect of this biphasic beast that tends to metastasis according to the literature i have come across. I see there is a thread below with respect to GBM and metastais to spine and this is well documented as well. I will attach a few links that support the wikipedeia stats as well. I would also agree with "siblingof" that if u do not have a NO you need to seek one out fast. This became apparent to us in March when my wife's MRI showed enhancement.( Although we have a excellent NO out of town we thought it would be good to have a onclolgist locally that we could work with as well. ) . When we met with the local oncologist after the MRI in question and going over it with her we were shocked to see her pointing to parts of the brain that were not even in question. She was clueless with all due respect. She just doesnt have the experience to deal with this. (By the way my wifes has a gliosarcoma as well and is doing fine. only one year out).
Here is a extract and a few links:
Extracranial metastases from cerebral gliomas, including GBM, are very rare, while the propensity for gliosarcomas to metastasize is well established. Even in the early days of Feigin, several authors reported cases of metastatic foci that contained admixtures of both gliomatous and sarcomatous elements [2,31,32]. The presence of these metastases was a large contribution to the premise that PGS are a clinically separate entity from GBM and truly biphasic in nature. Smith and colleages  in the largest metastatic case series to date of seven cases of gliosarcomas, observed that in two cases, the metastatic foci were composed solely of the sarcomatous component. Other case reports followed with similar findings of sarcomatous elements alone in metastases [25,34–36]. These observations have generated the belief that the metastatic potential of gliosarcoma is due to the sarcoma component and ultimately reflects the strong propensity of sarcomatous neoplasms to disseminate hematogenously.
Most extracranial metastases of gliosarcoma are located in the lung and liver, and there are reports of metastatic foci in cervical lymph nodes, spleen, adrenal glands, kidneys, oral mucosa, skin, bone marrow, skull, ribs, and spine [10,31–40]. Intramedullary metastasis to the cervical spine has also been observed . There is a rare case of widespread extracranial metastases with intravascular tumor emboli, which is also consistent with the concept that gliosarcoma metastasize via a hematogenous route .
by yankmom on Sat Jun 23, 2012 04:12 PM
by siblingof on Sun Jun 24, 2012 12:22 AM
by GBMBGONE on Mon Jun 25, 2012 02:00 PM
My heart goes out to your son and his family. It just doesn't seem fair. I have no words to say. I know how hard it was for me when i had to sit our two children down and explain the circumstances to them. When my 10 year old (at the time) daughter asked if "mom was going to die' . How do you answer that? I too remember being "mad at GOD". My wife's faith is so incredibly strong, and i just kept wondering how god could allow this to happen. I will keep your family in my prayers and will pray for miracles.
by yankmom on Mon Jun 25, 2012 03:30 PM
by yankmom on Tue Jun 26, 2012 12:16 PM
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