My mother was on Nexavar for about 8 months, her labs stayed pretty good other than her red count would go down pretty low. If these treatments are not working well for him you may want to consider Interleukin 2 treatment. It is similar to Interferon, but it is at a much higher dose. It has to be done in the hospital, and he would have to stay for a week after the dose to be monitored, then off for two weeks, then back in the hospital for another dose staying another week, then a month off. This treatment is the only "Curative" treatment that has been found sofar. All of the new medicines like Nexavar, Avastin, Sutent have had a few rare cases of curing the cancer, but Interleukin 2 has a lot more success. The only downside to the treatment is the side effects being severe and the hospital stays. I wish you luck and will keep your family in my prayers.