It really isn't a minor thing. When my husband had the third gemcitabine IV his arm started swelling during the infusion and he had awful pain in his arm. He complained to the nurse about it, but she said that sometimes happens. By the time he left, his arm was three times it's normal size. We asked the oncologist about it and he was a little concerned because it has obviously infiltrated the muscle. It also caused overall swelling, especially his eyes, face, hands and to some extent, his legs. I think either the nurse went thru the vein into the muscle or his veins were at the point of being very fragile. He was told to put ice on it and come back the next day. It took weeks for the swelling to go away. Needless to say, that was the end of treatment at that cancer center. He started treatment a couple of months later at MD Anderson. The nurses, doctors, physician's assistants and radiation techs are much more careful and caring.