Sutent to Nexavar to Affinitor, what is next?

After 20 months on Sutent, 13 months on Nexavar I am heading over to Affinitor.  In trying to stay ahead and see what the future holds, what it the protocol after Affinitor?  It would apprear that Affinitor is good for about 12 - 18 months but of course, it all depends on what is happening inside.  It helps me to map out and see what the future holds.  Thanks All.

My husband has been dealing with renal cancer for almost seven years now and has been through several different medications.  None worked as well as Sutent.  When it stopped working after three plus years, we tried others.  Nothing worked.  Then we went back to Sutent again and it started working again!

Dianna

My husband is seeing a doctor next Thursday about the clinical trial of Afinitor (everolimus) and Avastin (bevacizumab) in combination. 

http://clinicaltrials.gov/ct2/show/study/NCT01198158?show_lo

 There is also Inlyta (axitinib).  I do endless research on the subject and I ran across this article.  It explains why you should change from one therapy to another.

http://www.springerlink.com/content/707j9440x111x372/fulltex

It is a medical article but by looking up a few terms I was able to follow it.  Paticularly the chart in section 6 on sequential therapies.

 Please post if you run across any other therapies.

Thanks,

Kelly C

On Nov 10, 2012 10:57 PM Diannab wrote:

My husband has been dealing with renal cancer for almost seven years now and has been through several different medications.  None worked as well as Sutent.  When it stopped working after three plus years, we tried others.  Nothing worked.  Then we went back to Sutent again and it started working again!

Dianna

Hi Diana,

I've been on Tivozanib (clinical trial).  It's going to be approved sometime around July of this upcoming year.  I've been on it for 13 months now.  In the beginning it reduced the size of my tumors across the board.  They are now stable and not growing or shrinking.  My onc says in our world stable is good.  Side affects aren't too bad.  I'm supposed to have high blood pressure but I'm one of few who don't.  Some occassional bowel issues but nothing too severe.  I take one pill a day for 21 days then take 7 days off for my body to recover a little bit.  The cancer is in my shoulders (they radiated those tumors last February), my left adrenal gland and some spots on my lungs but they aren't convinced the spots on my lungs are cancer.  Could be blood clots.  They never change.  My left kidney was removed 3 years ago when all this started.  It came back a year ago.  I hope your husband does well.  Ask your ONC about the tivozanib when it gets approved.  

Hello,

My dad was first diagnosed in 1994 and in 2006 RCC was found in his lungs and spine.  He has been on Sutent, then Torisel (infusion drug), Afinator and Votrient.  He just started Inlyta.  There are also more in the pipeline so keep the faith!

Others have mentioned drug possibilites in this situation. My sequence was Sutent, Afinitor (helpful for 1 year each) Axitinib (ineffective) and now I'm on Votrient. Even the kidney specialist at a hotshot teaching hospital said, in effect, that it's a crapshoot at this point. All these agents are so new that there are not sufficient data to determine an optimal sequence. My wish was for quality of life over quantity, and I have to say that everything but Sutent was quite tolerable with only minor side effects.