I don't know much about adenosquamous vs adenocarcinoma version but word aggressive and pancreas make me wonder why xeloda vs. folfox or folfirinox or some other combination. After the radiation with chemo will they give her some other chemo mix? If she is healthy enough overall they more aggressive chemo. They may give one chemo with radiation and maybe other chemo later. I was given 5FU with radiation and xeloda after (6 cycles) and both break down to 5FU. The drugs of choice for most pancreatic would not be xeloda, I had related ampullary cancer and if any nodes were involved I would have gotten oxaliplatin too. Folfox and folfiriniox include oxaliplatin. The choice is based on health of patient, aggressiveness of cancer, etc. Age alone isn't only factor in what is used. If she stays on xeloda, use cushioned shoes and heavy lubricants on feet with socks at night and if needed gloves and balms on hands too. If she gets hand/foot syndrome it is common, temporary, and dosage can be altered, and is associated with more benefit from drug. Also, for many of this class, if need vit. B6 and maybe l-glutamine. good luck, you have your hands full and hoping your husband has been doing ok. Encourage your mom to take probiotic daily and during radiation she needs to be on omeprazole/prilosec to reduce risk severe gi ulcers, if she is not on it, discuss with doc asap. Usually it is given with enzymes for same risk. Look into more veggie based diet, limiting or stopping animal proteins, maybe some organic/natural if any. I do alternatives to dairy, alternative to meat like mostly deep sea fish/ farmed in Canada seafood and domestic shrimp and scallops plus soy-based fake meat substitutes. I find coconut milk products helpful after whipple as bypass liver for digestion. J in NH