aml tryals with Vosaroxin

I was diagnosed with AML on May 6th 2011 and was hospitalised on the 8th of May. My AML was too far for undergoing conventional treatment and the hospital invited me to join a French research programme "Chemotherapy  induction type LIA,LAMSA maintenance REV 5AZA"

Now some 20 months later, the treatment failed and the Medical team here in France proposes an other research programme, based on Vosaroxin, a study of Vosaroxin or Placebo in Combination With Cytarabine in Patients With First Relapsed or Refractory Acute Myeloid Leukemia (AML)

Does anybody has any experience with this kind of research programme??

Willem

On déc. 01, 2012 3:30 SusanLB_1 wrote:

I don't think I would try anything if there was a chance of getting a placebo. What are your blasts? Do they want you to go back into remission so they can do a transplant?

Hi Susan,

Donot know about the blasts and I don't think they will do a transplant at the age of 66.

I am 66, born february 1946

Hi Susan,

I found the Website whith the protocal of the research programme:

http://www.sunesis.com/data-pdf/595/sunesis-vosaroxin-201011

Hope to hear from you soon.

willem

Willem

My mother has started on Vosaroxin trial that you mentioned below.  It has 2 arms: control arm with cytarabine intermediate dose plus placebo and test arm with same cytarabine plus vosaroxin.   Anyone who is participating is getting cytarabine intermediate dose and may or may not get the new drug. 

Cytarabine intermediate dose is not the best approach to put someone in remission as there are some other agents (e.g., 7+3 or MEC protocol for when 7+3 didn't work).  However, I guess because of my mom's age, intermediate dose of cytarabine would be the most she can handle, that is why trial was not a bad option for her.

She is 74.  She is Russian but got sick in the US while visiting me.  She may be a candidate for a transplant and had a consult; which raised some eyebrows when we mentioned to Russian doctors.   Will see where this treatment takes us.

Good luck to you