experiences with Folforinox

Hi,

I'm Anna from Holland and found the CancerCompass. My husband is diagnosed with pancreas cancer andmetastasis in the liver. He is on Folforinox now and he's is reacting very good on it. Nearly no problems during chemo; he gained weight to normal (lost 10 kg) and has already had 10 treatments. So we are very happy. The tumormarker dropped from 950 to 37 and the metastasis in his liver are shrinking. Now we want to know your experiences. Because we think it wil be good to go on with it. Can someone help us with information about Folforinox, because we like to continue with the treatment.

Bless you all,

Anna

On Dec 05, 2012 12:08 PM Anneke wrote:

Hi,

I'm Anna from Holland and found the CancerCompass. My husband is diagnosed with pancreas cancer andmetastasis in the liver. He is on Folforinox now and he's is reacting very good on it. Nearly no problems during chemo; he gained weight to normal (lost 10 kg) and has already had 10 treatments. So we are very happy. The tumormarker dropped from 950 to 37 and the metastasis in his liver are shrinking. Now we want to know your experiences. Because we think it wil be good to go on with it. Can someone help us with information about Folforinox, because we like to continue with the treatment.

Bless you all,

Anna

Hi Anna,

First let me wish you and your husband a Merry Christmas, I am from Canada but have relatives in Holland.

I started folfirinox last November had quite a few side effects for the first few months then it level out, so glad to hear your husband is reacting so well to it, I had 16 treatments with a 30% shrinkage, I came off all treatment last June due to severe tingles in the hands and feet after scan showed every thing was stable had another scan September which also gave me good results still stable, January I am scheduled for another scan, if it shows any changes it will be back to folfirinox but if it is still stable (fingers crossed) I will continue without treatment.

I feel good, eating well energy level good, I pray that the folfirinox is the answer to pancreatic cancer but it is still early days, when I was first diagnosed September 2011, I was told I had 3 to 9 months. Blessings to you both and keep updating.

Sheann

10 months of Folfirinox in conjunction with Metformin put my wife in remission since June of this year. She was diagnosed with inoperable stage 4 pancreatic cancer with mets in her liver. The truth is Folfirinox will only kill a certain group of stem cells not all. You will need additional drugs like Metformin to target those cancer cells which chemotherapy can not eradicate and prevent the tumor from growing and spreading. Read this most recent report on the advantages of treatment with this anti-diabetic drug published in the American Association of Cancer Research: In clinical studies Metformin treatment caused cancer stem cell death in pancreatic cancer cell lines. Results of some preclinical trials have shown that low doses of the drug may effectively destroy cancer stem cells, a group of cells that are considered to be responsible for tumor initiation and, because they are resistant to standard chemotherapies, tumor relapse. In addition, when metformin was combined with a standard chemotherapy used for pancreatic cancer, the combination treatment was able to efficiently eradicate both cancer stem cells and more differentiated cancer cells, which form the bulk of the tumor.

Hello Maxxschiken,

 

Do you know if Folfiri has positive long term effects for esophageal cancer, my husband diagnosed with stage iv, has been on Folfiri and ironticinin for 6 months, last scan was good, NED.. he will have to continue on this regimen for a while more... just wondered if there will be a good outcome with this regimen.. he looks well, good appetite... no difficulty swallowing etc.. I can only hope that it is working and will continue to eradicate the cancer cells.

Thanks,

 

On Dec 05, 2012 11:00 PM maxxschiken wrote:

10 months of Folfirinox in conjunction with Metformin put my wife in remission since June of this year. She was diagnosed with inoperable stage 4 pancreatic cancer with mets in her liver. The truth is Folfirinox will only kill a certain group of stem cells not all. You will need additional drugs like Metformin to target those cancer cells which chemotherapy can not eradicate and prevent the tumor from growing and spreading. Read this most recent report on the advantages of treatment with this anti-diabetic drug published in the American Association of Cancer Research: In clinical studies Metformin treatment caused cancer stem cell death in pancreatic cancer cell lines. Results of some preclinical trials have shown that low doses of the drug may effectively destroy cancer stem cells, a group of cells that are considered to be responsible for tumor initiation and, because they are resistant to standard chemotherapies, tumor relapse. In addition, when metformin was combined with a standard chemotherapy used for pancreatic cancer, the combination treatment was able to efficiently eradicate both cancer stem cells and more differentiated cancer cells, which form the bulk of the tumor.

Hi Maxxschiken,

I find your messages very inspiring, your wife has had such good results, I am very interested in Metformin that you mentioned helped a lot with the chemo, at this time I am not diabetic but I will talk to my Doctor, is this a clinical trial if so there is a possability that it hasn't been accepted here in Canada, any information you could give me would be very much appreciated, started folfirinox September 2011 and I have been off it since June, very similar but I am not in remission 30% shrinkage.

Blessings Sheann

At this point, it doesn't seem to matter whether you are diabetic or not in order to have access to Metformin. Here in the US patients with breast, colon and all sorts of cancers are responding to Metformin. Also a metastasized stage 4 diagnosis is still considered and viewed by the medical community all over the world as TERMINAL and FATAL. These patients should be allowed to access whatever form of medication they need that might assist with prolonging life or even a cure! There are already confirmed cases of remission in many forms of cancer when Metformin is used in conjunction with standard chemotherapies. In my opinion, move fast to access this drug as if it were your last ditch of hope for a cure!

Hi Sheann,

I'm so glad with your reaction. The important thing is that you are still here and that you are still stable. I pray with you that folfirinox is the answer. My husband has a strict dieet regime. He does'nt eat any sugar at all or as less as possible. Much fruit and vegatables and vitamines as D,D3,K2, fish oil and codoil. Maybe the combination of less of no sugar and folfirinox are also working?

Anna

On dec 05, 2012 8:11 sheann wrote:

On Dec 05, 2012 12:08 PM Anneke wrote:

Hi,

I'm Anna from Holland and found the CancerCompass. My husband is diagnosed with pancreas cancer andmetastasis in the liver. He is on Folforinox now and he's is reacting very good on it. Nearly no problems during chemo; he gained weight to normal (lost 10 kg) and has already had 10 treatments. So we are very happy. The tumormarker dropped from 950 to 37 and the metastasis in his liver are shrinking. Now we want to know your experiences. Because we think it wil be good to go on with it. Can someone help us with information about Folforinox, because we like to continue with the treatment.

Bless you all,

Anna

Hi Anna,

First let me wish you and your husband a Merry Christmas, I am from Canada but have relatives in Holland.

I started folfirinox last November had quite a few side effects for the first few months then it level out, so glad to hear your husband is reacting so well to it, I had 16 treatments with a 30% shrinkage, I came off all treatment last June due to severe tingles in the hands and feet after scan showed every thing was stable had another scan September which also gave me good results still stable, January I am scheduled for another scan, if it shows any changes it will be back to folfirinox but if it is still stable (fingers crossed) I will continue without treatment.

I feel good, eating well energy level good, I pray that the folfirinox is the answer to pancreatic cancer but it is still early days, when I was first diagnosed September 2011, I was told I had 3 to 9 months. Blessings to you both and keep updating.

Sheann

Hi Sheann,

I'm so glad with your reaction. The important thing is that you are still here and that you are still stable. I pray with you that folfirinox is the answer. My husband has a strict dieet regime. He does'nt eat any sugar at all or as less as possible. Much fruit and vegatables and vitamines as D,D3,K2, fish oil and codoil. Maybe the combination of less of no sugar and folfirinox are also working?

Anna

On dec 05, 2012 11:00 maxxschiken wrote:

10 months of Folfirinox in conjunction with Metformin put my wife in remission since June of this year. She was diagnosed with inoperable stage 4 pancreatic cancer with mets in her liver. The truth is Folfirinox will only kill a certain group of stem cells not all. You will need additional drugs like Metformin to target those cancer cells which chemotherapy can not eradicate and prevent the tumor from growing and spreading. Read this most recent report on the advantages of treatment with this anti-diabetic drug published in the American Association of Cancer Research: In clinical studies Metformin treatment caused cancer stem cell death in pancreatic cancer cell lines. Results of some preclinical trials have shown that low doses of the drug may effectively destroy cancer stem cells, a group of cells that are considered to be responsible for tumor initiation and, because they are resistant to standard chemotherapies, tumor relapse. In addition, when metformin was combined with a standard chemotherapy used for pancreatic cancer, the combination treatment was able to efficiently eradicate both cancer stem cells and more differentiated cancer cells, which form the bulk of the tumor.

Hi maxxschiken,

I'm glad you wrote about Metformin as a additional drug. Tomorrow we have a appointment with my husband's oncologist and i will tell him about it. I'm so glad that it has such an effect on the illnes of your wife!!! After 10 treatments he is in such good shape that i think there must be more to help my husband. I'm so glad i found the CancerCompass,

love Anna