Annual cost of lymphedema treatment fell $12,000, study found
by boisid on Mon Jan 07, 2013 02:18 AM
Hello all and happy New Year,
For several years now I have been taking 1000 mg/day of hydroxyurea and it consistently keeps my platetlet count at around 350000. Well last year, around Q2 as I recall, my prescription plan was changed from Express Scripts to CVS Caremark. When I received my first 90 day supply of the hydroxyurea I could see that it was a different capsule color and that the generic manufacturer was different.
Fast forward around 3 or 4 months and all of a sudden my count, on 2 measurements, 1 month apart, was around 420000. I brought up the fact that the generic supplier changed and my doc said they certainly have seen changes with a change in generic manufacturers.
OK, I then proceeded to call CVS Caremark and spoke to a poharmacist. He agreed to have in my records that I only get hydroxyurea made by Teva-Barr (formerly Barr Laboratories who was acquired by Teva).
Now, after 3 months or so on the Teva-Barr product my last count, taken last week, was 352000.
So, I wanted to elt you know. I should also tell you that with Rx drugs, the FDA allows plus or minus 10-15% from what is stated as the dosage. So 1000 mg could be as low as 850-900 mg, and there is no doubt in my mind that this is what happened in my case.
I checked with a cycling firend of mine who is both a pharmacist and attorney who deals with regulatory and FDA issues. He confirmed what I stated above as to the plus/minus 10-15% issue, and he also noted that when changing from 1 manufacturer, or manufacturing site, to another it is recommended that a dose response study be initiated.
I hope this is helpful.
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