HLA-B27: People who are positive for HLA-B27 are at higher risk for certain autoimmune diseases including ankylosing spondylitis, Reiter's syndrome, certain eye disorders such as acute anterior uveitis, iritis, psoriatic arthritis and inflammatory bowel disease. Just because a person is HLA-B27 positive does not mean they will get any of those diseases, they are just at higher risk. I find no references that HLA-B27 has anything to do with multiple myeloma.
Eosinophils 4.1% - To me this does not seem high. I have always thought the normal range was 0-5%. Eosinophils do lots of things such as fight viruses and parasites, but they are best known for allergic reactions such as asthma.
ESR 16 - To me this does not seem high. The normal range varies a little based on age and sex, but it is commonplace to see numbers between 0 and 15. ESR is a nonspecific indicator of inflammation. It says there is inflammation somewhere. It does not say where nor why. 16 does not seem high to me. If your doctor is worried he can do a slightly more specific test called a C-Reactive Protein (CRP).
When a page or two of blood tests are done on normal people, there are always a handful of numbers out of the normal range. It is extremely rare that anyone has a page or two of numbers that are fall into the normal range.
Call your own doctor and ask for a copy of the last 10 pages of bloodwork done on you - do not be surprised to see a handful of numbers outside the normal range as well.
On a separate note, keeping good health records of yourself and your family at home in folders is a good idea. That way you can compare previous bloodwork or other tests with current bloodwork yourself. For example, if your husband's PSA is normal (0-4) last year and this year but the number went from 0.4 to 3.4, that is something to worry about.