I have the same problem, about the third week, I am treating the hand and foot thing with 2 doses of 100 mg. B-6 daily, which seems to help, but I am about out of my mind with itching and irritation--evertyhing that touches my skin is more than annoying, my skin burns and itches, and then it gets all dried up and dead and peels. No one at the cancer center has ever seen it before. Nice. What do you do about it?