I started taking velcade 3 months ago. I only took one treatment and my IGg has gone down to 700 from 1700 over the past 3 months. My doctor stopped my treatments after the first one. Is any one else taking this same treatment? Now that my IgG counts are so low my doctor says that they may have to give me something to help with my immune system. Has anyone else had any experience with this new drug? please let me know. thanks Darlene