The bone marrow biopsy is painful but you do not need to loose work over it. I had a biopsy of a cervical node in my neck for which I was hospitalized. I don't remembe how many days. I had biopsy of my intestines which was done with a bowel resection where they took out part of my intestines, so it was a regular surgery with a biopsy included. If they can use a needle guided with x-ray to get the biopsy, it shouldn't be bad, or require hospitalization. If they have to do surgery to get to the area, then it will require a surgery and depending on how large of an incision they have to make and how deep they have to go will determine the amount of hospitalization time required and time off work required. What type of work you do would also be a factor as to when you could return to work if you require surgery for this biopsy. Hope this has been helpful. Let me know if you have any other questions. God Bless!