Hi again, the alternative drug to oxaliplatin is called irinotecan. Maybe its not considered an alternative in the US but many studies have been done worldwide. Its a little bit less effective than oxal. They had some studies where they switched from oxal to irin because of the neuropathy (an also vice versa). It was difficult for me to determine the effectiveness, not being an expert (I read the presentation given to an international oncology meeting). I assume you had stage 3 colon cancer so are not allowed to go for these new drugs (avastin and erbitux) which seem to do wonders for stage 4 cases. It seems avastin or erbitux + irinotecan is now a standard treatment for stage 4 and avoids the neuropathy problem quite well. Thats what I know. You might do a Google search on standard stage 3 colon cancer treatments. Best of luck, Alan.