My Mom was diagnosed with rectal cancer in the fall of 2004. She had surgery followed by several rounds of 5FU and radiation. After a six month break her CT scan showed it had metastsized to her lungs on both lungs and several small spots so it was inoperable. She started on Folfiri and has had 21 rounds to date. She has tolerated it well but feels pretty lousy for the first 5 days after treatment. She takes Kytril and steroids. She started on a 2 week cycle, went to a 3 and has been on a 4 week one for quite a while now. She also had a 20% reduction as she couldn't tolerate a full dose. Her last 2 CT scans have shown a small amount of growth on one tumor on her lung. The other tumors remain stable and her original site and other organs show no signs. Her tumor has grown from 1.5 cm to1.9 and seems to grom about 2mm every 3 months. They are now trying to decide if it is time to change to FOLFOX. I hear about all the scary side effects and not sure if we shouldn't take a few more months of the slow growth before we start. However if the FOLFOX can stop the growth or help shrink the tumors maybe we should start?? How long can you be on FOLFOX as a second line of treatment? Our Dr. says some patients have a good run on it for years but I don't hear of that very often. Will her side effects become too hard to handle?? Any comments or experiences you can share would be helpful. Thanks to those who reply and good luck to eveyone in their fight.