My husband had an allogeneic mini-transplant in 11/05. It was a 10 point, female, unrelated match. He ended up the first month with GVHD of the skin and gastro. After putting him on prednisone, he faired well. His gut GVHD healed and his skin finally got better in about 6 months. Just before his 1 year check up he got it back again and in December it flared with a vengence. With all the high doses of prednisone he has gotten Stage 3 kidney disease and asvascular neucrosis in his hips. He finally got off the prednisone this past July after a long taper and now his gastro GVHD has returned and his skin GVHD has flared. They want to put him on prednisone again or give him a new shot that has had very little success for GVHD and has many side effects (severe infections, cancer). He has been hospitalized since November for many pneumonias and is susceptible to infections. Does anyone have any ideas? We are desperate. He has been on every type of immunosuppressant, has done total body irradiaiton, and ECP (photopheresis) treatments. Help, we are desperate and his depression is getting worse. It would seem someone out there has been through this and has come through. Please help.