I would like very much to hear from someone who has knowledge about clinical trials.My brother just had all his tests run agin followoing about 4 months of hormone therapy, and 3 weeks of radiation, and it showed that the cancer is in more spots now then when he started treatments. The Doctor told him that he could try a Clenical Trial. When the remainder of his tests come back which should be soon now, and another MRI to see wheather the cancer has gone to any of the organs, then we will know what the combination drugs will be. The Doctor said that it would consist of two different drugs and talked like it would be given in a form of chemo. He would take a treatment every 3 weeks, then be checked to see if it was helping. Maybe there is some of you who have or are under going Clinicals Trial Treatments or know of someone else who has. I would be most greatful to know more about it. My brothers Doctor told him that if one didn't work then they would try another. The Doctors can't understand why my brother has no pain, and feels good, with the metasized stage 4 cancer that he has. It is in is spine, Pelvis bone, both shoulders and leg. It is a very agressive cancer, so they would like for him to start the treatments as soon as possible. It is a difficult decision for him to make, since he feels good now, and don't know what the chemo might do to him. Will he continue to have quality life for whatever time that would be if he doesn't take the chemo. or will the chemo clinical trial make him livery sick, and do more damage then good by taking away his quality of life as he has it now .I believe that he is going to take it, because it does offer some hope, and he wants to live as long as he can, if it is quality life.. I know that this next question probley sounds pretty dumb, but does the cancer go to the lymph glands before it goes to the bone, or does that come later? I had just assumed until I read something yesterday, that once the cancer gets outside of the prostrate, that it goes to the lymph nodes and that it then gets into the blood stream, and that is how the cancer spreads to other areas, however I read something different the other day. I truly appreciate so much your taking the time to read my long letter and will be so greatful for any information regarding Clicical trials and what you think about them. Thanks so much again. Gracie