I have been on Lupron Depot for the past year and a half. Results were good, in that my psa dropped from 40+ to 0.2 and has been steady. Side effects were hot flashes, severe fatigue and muscle weakness, but a stringent exercise program seems to be helping. Problem is that when I suffer a hot flash I have a lot of pain in my legs, predominantly in my knees, and lower shin down into the foot. I have been asking my Dr. about this, and it is dismissed as not being noteworthy. My question is, has anyone else suffered similar symptoms? With the number of people on Lupron, there should be some information available.
Second issue is: I have considered going on Intermittent Therapy, ie: laying off lupron for a while to attempt to lessen the side effects, andperhaps, prolong the time to becoming refractive. It has been 6 months since my last injection, and while I have not had a psa test to determine the effect on that level, my side effects have not changed a bit. It even appears that I may be seeing a "bounce" in the effects. Again, anyone with any information on personal experiences?
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