My husband has Stage IV Mal. Melanoma...he has three tumors in his brain (he has had 3 gamma knife, craniotomy and full head radiation) and has two tumors in his liver that have shrunk under the use of 6 cycles of Temador however we just got news that there is now a third spot in the liver about 1/2 inch in size with the other two still remaining stable. The decision is this...should we stay on the Temador knowing that it has the potential of crossing the blood brain barrier and had kept two spots stable or try this new chemo with carboplatin and taxol? Does anyone have any insight in helping us make the right decision? Thank you so much.