Brenda, My 81 yr old mom has been on Tarceva for 3 months and has gotten dramatic improvement in her stage IIIb non small cell lung Ca. She is symptom free, her lung tumor and liver mets have shrunk, and says she is breathing better then she has for a very long time,and is back to being very active again. The only side effect she has had has been the rash and even at its peak it was tolerable. The rash has improved quite a bit now. No one knows how much time Tarceva will buy her but what is important is that it has given her back her quality of life . She takes her pill once a day and that is it. Tell your Grandma it is worth a try . Most people I have talked to the rash has been the side effect and some papers I have read have said that people that develope the rash tend to be people that the drug is working for. Good luck to your Grandma. Let her know she is not alone as there are many out there facing the same decision she is. JanMarie