My father was diagnosed in December 2005. Fatigue is a big issue. We have seemed to conquer this with natural juicing, carrots, apple and parsley, glyconutrients and vitamin B supplements. He too suffers with spleenomegaly a common occurance with this diease as the organs are trying to store and "make" the marrow the bones cannot. I would suggest that you really research Revlamid. The recent study going on at my hospital had large numbers of drop outs due to the side effects. There comes a point in time where you stirve for quality of life not quantity. Not all cures come from a pharmacy. No doctor is "all knowing". They put their pants on one leg at a time just like us. Do your homework. Research, research, research. I have spent countless hours in a medical and regular library. Find a physcian that will talk on your level and see you as a person not another office visit. Support and attitude go a along way with any terminal dieaase. Keep you chin up. Celebrate every point that gets better in the lab work. Juicing also helps get required nutrients and seems to be easier to tolerate since at times he doesn't feel like eating due to the presssure of the spleen on the stomach. Wishing you the best!