Hi Zazu1234 -- Perhaps your brother may be helped by the the 3 drug combo mentioned by Craig in his message today (12/12/07) -- its certainly worth asking his doctors. The research over the past few years has been aimed at making MM a 'chronic' rather than a 'terminal' disease. These 'new' drugs have been given to those of us who have had everything else and for whom there didn't appear to be any hope, but the knowledge gained from these trials has shown just how effective the drugs can be so now they are looking at giving them to the newly diagnosed. This is fantastic for it means that we are much closer to a chronic disease situation. Unfortunately because MM is so unique it is difficult to find one drug to cure all and therefore people need to keep trying to find the drug that works for them. Some get good results from Thalid, others from Velcade, and those like me who respond to Revlimid. I've had the lot, for varying lengths of time due to the particular side effects which I have experienced. However each of these drugs gave me more months than were initially told to me at the point of diagnosis. Because I believe that the Revlimid is now starting to loose its potentcy for me I am starting to look for the next 'new' treatment. Hopefully it will continue well into 2008 and I will find something new before this really fails -- but by taking a proactive approach I honestly believe that I can make a difference. After all, I was the one to recommend Revlimid to my oncologist after I read all about it on CancerCompass and the net almost 2 years ago, and I've honestly had the best year of my life since diagnosis!! Good luck for your brother -- with you advocating and supporting him I'm certain that you will make sure that he gets the very best of treatment. Have a look at the Cancer Treatment Centres of America site -- I know that if I lived in the USA I'd certainly be going into my nearest hospital and listening to what they had to offer. Hang in there -- it is treatable (for nobody knows how long) and there is help for pain which makes it liveable. My thoughts and prayers are with you, your familly and especially your brother. Cath