Yes, I had radiation and chemo together for a 3-4 month period. I would go to radiation at 8:00am, then be at chemo by 10:00am, finish chemo at 3:00pm and then be at work at 4:00pm and pull a 12 hr shift-grit. I never missed a day of work. Mind set...Towards the end of radiation my chest was really burned. Ensure that the skin gets plenty of ointment/salve to make the burning less severe. My oncologist asked if I wanted to switch to Tarceva, at this time I told him no. Maybe in the future. I am reluctant to change from something that obviously works for me.