My friend, diagnosed in March 2007, with metastatic melanoma, has responded well to Temodar and a variety of other meds, for a reduction of 50% of original tumors. All lymph system tumors are gone. However there are three (I believe) very small tumors in his lungs that have not responded. They have not grown, but have not reduced either. Now, a couple of weeks ago, his MRI showed 3 tiny spots in his brain. He is back on Temodar combined with Thalidomide on a daily oral basis and a once-a-month dose of Lomastine. Today completes the first week of this treatment. Side effects are pretty severe - nausea, dizzy, weak, etc. Does anyone have any experience with the drug combination?