My husband has been on sutent for 12 months and the main tumor has shrunk more than 50%. He also has small tumors in the liver and vena cava that have been there since the cancer was discovered. There has been no further spread of the cancer which we have been told is unusual. The oncologists recommend surgery before he develops resistance to sutent which should occur soon. We understand this is major surgery with lots of risks that only a few doctors in the country would attempt. Our GP estimates my husband has another year to live (most of it pretty good) even if sutent stops working soon. If surgery is successful there would be a 3 - 6 month recovery period with unknown survival period or quality of life. My husband is leaning against having surgery and enjoying what time he has left traveling and visitng loved ones. Questions - Has anyone had surgery to remove a kidney and parts of liver and vena cava after taking sutent? Would you have the surgery again knowing what you know now? Has anyone been taking sutent for more than a year? Will his resistance to the drug be obvious to us when it occurs. His only side effect in recent months has been hand foot syndrome.