My late brother, who died of HCC in late September 2007, had one chemoembolization, followed by systemic chemo with Adriamycin for 3 months. When the Adriamycin failed to stop tumor progression, he was switched to Nexavar for about 3 months.. While on Nexavar, he consistently experienced serious diarrahea. On the advice of his oncologist, he attempted to control it with various meds/strategies but nothing worked for longer than a couple of days. We never really knew how much of the diarrahea was a side effect of Nexavar and what was caused by disease progression. Your loved one's oncologist would be the best person to ask for further information.