My Dad has been on Tarceva 150mg since March 2005. Side effects for him have been a acne like rash on his face and neck. We have tried a few thing for the rash. Recently he has begun washing with Dial soap 3 times a day. It has seemed to help. Not sure if it is the soap or just his body getting use to the drug and the rash going away. Some have said the rash improves over time. He also has cracks in the tips of his fingers. Other than these two things he has tolerated the drug quite well. Doctor wants him on it another 2 months and than a CT scan to see how it is working. The drug has not been out for very low approved for Lung Cancer in the Fall of 2004. I have not been able to find anyone on the drug more than a few months. There is also a new drug called Avastin. It is used with Chemo and has had promising results in trials. We are hoping it will be approved for Lung Cancer Treatment soon and will try this drug next. God bless you and your husband in your journey.