Generally speaking, MM is not a cureable disease with the possible exception of a stem cell transplant. Because the SCT has a high mortality of its own, especially in the elderly, it is rarely an option. Early treatments are often effective but the disease usually returns. So it is a constant battle using different drugs to fight recurrences. I agree pain control is essential for quality of life. If the vertebral fractures are bad surgery (kyphoplasty) may be an option.