I am on my sixth round of Sutent, finishing the 31st of Jan. My first round was at 50mg and was very difficult with nausea, hand and foot syndrome, mouth sores, fatigue and edema. I was taking radiation treatments at the same time. My onc dropped me to 25mg for the second course and that was no problem; almost no side effects. I went to 37.5mg on the third and again I handled it well with minimal side effects. My last three rounds have been at 50mg. Nowhere near the side effects of round one, however the last week I feel a lot of fatigue and my taste buds go away. My side effects last well into the second week of my time off and thus I only get a few days of "feeling good". Luckily the first 10 days or so are pretty much side effect free.
Richard Catlett