Truths, are you also a "face man/lady"?
5-FU does its work for the first weeks pretty much undetected until the "erosion" stage, when the bad DNA can't make the RNA for new cells and all start dying off, so the changes are normally going to be more dramatic about 14 to 21 days. For me day 20 and my arms went nuts. Face skin is different of course. But don't be applying anything until at least 3 hours after applying the 5-FU so the drug can work first. Regards, Whitey