Hard to believe female body builders use Arimidex when it is linked to bone loss........ I agree that it has a lot of crappy side effects. I too lost libido (after being thrown into menopause and having chemo & radiation). I went to a gynocologist who specializes in menopause and female cancer patients. She put me on vagifem first for the awful dryness and now I use the Estring. Yes, it secretes a tiny amount of estrogen (and I had E++ cancer) but she says it's confined to the vaginal area and I also decided that quality of life was important to me. My life has already been altered by the cancer treatment and resulting lymphedema. I wasn't about to give up my sex life too. Does the Estring put me back to where I was prior to cancer? No, but it has helped both with sex (now possible)and with the bladder problems so I'm satisfied.