Kevin if your numbers can not be reduced in chemotherapy this still does not mean they wont be reduced to the target figures . When you come out of remission you will be given a different combination of chemotheroputic drugs. Velcade, Lenolidomide, Revlimid. Thalidomide among others, once a response occurs you will be given the "high dose"chemotherapy and this will usually reduce the numbers to the desired level needed for successful stem cell transplant. All the best, RON