Hi - my mom has been on Sutent for 3 months now and depending on your dosage and method of taking it, the side effects are manageable. It is prescribed as 28 days on and 14 days off. My mom tried that and it kicked her butt. She is now doing 14 days on and 7 off. We have found that this works much better. She still works every day and her main complaint is her mouth. She gets mouth sores and a nasty taste in her mouth. It is NOT for the entire time. Her side effects usually start after a week, she tolerates them for another week and then during her time off she starts to taste again for a few days and then the cycle begins again. She has gotten bloody noses, fatigue, nasal congestion (it affects your mucous membranes), hand and mouth sores, very little nausea and only minimal hair loss. She is taking 50 mg but many people I read about have the dosage cut down to 37 mg. She has recurrent kidney cancer because she didn't need any treatment last time. She had cancer 14 years ago and had her left kidney removed. It has returned in her liver, lungs, and pancreas. The one in her pancreas in the largest at 3.4 cm - what was the size of the ones they removed in your pancreas? Good luck with your decision - Sutent is tolerable.