I have been on this message board for a long time....gathering information and listening to all of your advice etc. It has been very helpful both informationally and emotionally. My sister has melanoma that has spread from the primary (rectal) to her lung, liver, breast and is continuing to spread in her colon and pelvis area. She recently had a colostomy to help curb a blockage in her colon, but they did not remove anything. They are waiting for her to heal from this surgery (four weeks!!!!) and at that time she will go over clinical trials that would best suit her at the time. They are very concerned about the activity in her liver. My horrible question is.........is this the end of the line for her? what do we look for if it is? she is pretty weak, has alot of anxiety, she gets extremely tired toward late afternoon, and isn't eating as much as before. She has participated in two clinical trials so far and neither did much for her. She is being treated at UPMC in PA and is very confident in her doctor there. I know this looks horribly grim and I just want us all (family) to know what the end looks like, but I don't want to lose hope. She is so strong and young, but I see her fading and don't know how long you can go without treatment when your liver is in rough shape. Any information would be helpful. I pray for all of you going through similar situations!!! It is so hard on EVERYONE!