My doctor prescribed efudex for a small lesion of my face that was hard to see. I used it on my whole face, and I was really surprised to see my whole face break out like a bad case of measles. Now I am near day 14 of a 2x/day for 21 days treatment. I have to go to work, and I was wondering if anyone used a powder cover up, and would that affect the treatment.....good luck to anyone else going through this! Liz