I was recently referred to an gyn/onc for dysplasia of the vagina and vulva. I also have been diagnosed with lichen sclerosis. The oncologist prescribed Effudex to be used twice a week. After 3 treatments, the pain was horrible. The burning everytime I urinated made me shake. I waited for 10 days until my next appointment before doing another treatment. I was told I had lots of redness still from the treatments, to wait another 2 weeks before continuing treatments, and prescribed lidocaine to help with the pain and itching. I would be interested in hearing from anyone else who has undergone this type of treatment. I just never dreamed it would be so painful.