Thank you, Francese, for your helpful message. My wife is in her 2d round of 28 days Sutent, 14 day holiday. She had her right kidney out in January, 2005, the surgeon reported "clean margins", gave her a 75% chance of cure, but 3 years later the CT showed lesions in the liver & lungs. Our son is a 3d year resident in urology & an invaluable resource. As I understand her prognosis, she will be on Sutent until the lesions show growth in spite of it. She is tolerating the Sutent reasonably well, so my interest is what to do when there is progression of the disease. I am learning that the implications of any systemic treatment can limit options if that treatment fails. From what I have read on this site, it appears that others, after Sutent, have tried Torisel, Nexavar & Everlimus. I hope to hear of their experiences, which, for their sake, I pray are successful.
shalom