thank you so much for your reply, I shall copy this and let my vet read your reply. Toto has had her first chemo, no problems so far, she is now on Piroxcam daily, and seeing this can irritate the stomach, I am feeding her 3 small meals a day of Salmon & Potato kibble, which will not leave her stomach empty for acid to build up. She has her second chemo on the 18th July. I am finding that Toto is back to her old self, her confidence has come back, she was the Alpha female in the pack of 17 dogs, but when we noticed she had water works trouble she seemed to not want to be top dog. She did have a secondary infection of ecoli, which has now cleared up and she is more cheerful. She does not want to pass urine so much as well, also she takes less time to empty her bladder,especially when it is raining. Glad to read that JJ is respondin again to treatment also good to read about the other little female still having a quality of life after 2 years, I can only hope that for Toto. I will keep you posted.