My hubby was on Nexavar and had some extreme side effects with disease progression so he was set up to go on the RAD-001 trials but base line scans found brain mets so he missed out. He did go on torisel after the gamma knife surgery for brain mets, but the battle was lost for his after his 6th Torisel treatment, he could do no more. We did hear good things about the RAD-001 and wish you the best..