I'm replying because I lost my father to GBM in 1996. He did not have a second surgery and did not do much chemo. That was his decision after weighing the pros and cons of further treatment. That decision is very personal. I thought at the time that my father made the right decision to go out gracefully and spare his family as much pain as possible.
Now my wife has GBM and I am amazed at some of the options that are available. There have been siginificant advances in the past 12 years. The treatment is still considered pallative, but generally speaking the treatments are better tolerated and more effective. My wife is almost three years from intial diagnosis. So it is possible to stretch the odds.
One of the best treatments for recurrent tumor is Avastin combined with CPT-11 or another chemo. You should seriously look into this. It has a very high response rate and is generally well tolerated. My wife has been taking Avastin with Temodar since February and has had few side effects.
I wish Temodar and Avastin had been around in '96. I still think ultimately my father would have lost the battle, but I would have liked to have had more time with him. I miss him every day even after 12 years.