I spoke with my mom about Sutent (since we will find out if it has quit working for my dad) and she said that everyone is different... some people can continue on it for a long time, but sometimes 9 - 12 months is about the longest it will work. I don't know if the body becomes immune to it or what. My dad has been on it since July 07 and it shrunk some of his tumors, a few disappeared even! The rest have been stable. Then, five weeks ago, at his last checkup... they saw a shadow on the right upper lung... don't know what it is yet. They have him coming back next week to see if it is still there or what. They had him go ahead with this round, he just finished it Monday. Really, he has been very lucky with it so far... first round or two were really hard on his mouth and stomach. They gave him Prilosec for that and he takes Rolaids... he says really does better when he doesn't overeat which causes the stomach acid to churn up. Fatigue was his 2nd worst complaint. It started in the 3rd week and was terrible by the 4th week. Amazingly, they gave him ridilin for that... yes, the stuff they give hyper kids, works as a booster for adults that aren't hyper... he perked right up by the 2nd day. They said that Sutent may have taken us as far as it can, but if that is the case, there will be another plan of action. He has stage 4 RCC with mets to the bones and now possibly a met to the lungs. May 11th is his anniversary date - 1 year... we are celebrating by relaying for life on the 16th of May at my daughters college. We are ecstatic that he is doing so well, because his first oncologists told him he would not be here in 12-18 months... I think he is planning on proving them wrong... the oncologists he has now, say he could be here a very long time or he may go in a car wreck tomorrow... no one knows... just LIVE LIFE and take great joy in the things that mean the most! Best of luck to you and your family... you are in our thoughts and prayers!