My Mother has been on Gemzar for 4 months now for Stage IV PC, her CA19.9 numbers went down dramatically over those 4 months (although not nearly to the normal range - they went from 276,000 in the beginning to 9,000 at the best and are now back up to 30,000). Her Oncologist added Tarceva to the mix because he said that her body became immune to just the Gemzar. She's been on Tarceva for 2 weeks now and has broken out in a terrible rash on her face (which is said to be common). She has not been given an life expectancy time frame, but her doctor said that tarceva was the next step. I've done a lot of research ont heir site and they have links to foundations that will help with payment of this very expensive treatment. Just go to www.tarceva.com