Perhaps one of the medical professionals on here could comment about the politics of filing an incident report. I myself am not sure what that means in terms of the treatment your mother would receive or how that might affect her status in the clinical trial. Her neuro-oncologist would be best equipped to answer the question about the clinical trial status. I would find it hard to believe with as compartmentalized as hospitals seem to be, that your mother would suffer any backlash if such a report were filed. What would filing the report do in a positive way? Would the hospital absorb costs associated with the treatment? Would they reimburse your father for out of pocket expenses, or the insurance company for what they have paid for infection related procedures? I think more importantly if it brought the issue of infection to the forefront so the facility could deal with it proactively, that would be positive, but I can't believe that isn't automatically done when something like this happens.
As for dealing with complications from infections, I can speak to this a little. After my wife's craniotomy, she developed a infection at the surgical site that she spent the better part of a year fighting, that caused her to develop a large fluid buildup, resulting in three more surgeries, some of which would not heal. Finally 10 months after her first surgery, she had a radical procedure to correct the infected tissue, which has left her with her bone flap permanently removed and several skin grafts on her scalp. This interrupted her treatment as well, after completing the initial 6 weeks of radiation and Temodar, she had to wait about 8 months before beginning her 5/23 Temodar treatments. Her MRI's have been all clear since the end of radiation even with the long delay in treatments. Everyone is different, and I can relate to your frustration with the complications your mother is enduring, but hopefully she can begin treatments soon. Right now, the obvious issue is the infection. Good luck with everything, you and your family are in my thoughts.