Kara, I have to agree with mbg. Once a chemo stops working, (or in our case - never started working!) they must use try something else.
In my husband's case - dx 4/07/07 with inoperable GBM IV, left temporal / left parietal lobe - the radiation and temodar did not work at all and he had progression while on this treatment. Therefore, the plan to go to the higher dose of temodar was thrown out the window and he was immediately put on Avastin and CPT-11. He's been on that combo every other week since July 25, 2007 with one good MRI after another.
I think you have said since you are in Canada, you can't get this combination? I have no advice though on how you can get your doctors to approve this treatment.....
Warm wishes,
Barb