The combo has been easy on me. I've had 8 rounds, every 2 weeks since early January. Only real complaint is diarrhea, which has grown cumulatively worse over the last couple of months. It's pretty much a daily thing, but usually controllable by immodium. There is some fatigue like all chemo, but I'm doing far better than I was on temodar. 3 stable MRIs so far. I wish you the same good luck I've had.