My mom did the Avastin/CPT11 protocol for over a year, with amazing results, the was switched to just Avastin to keep the tumor away once her MRI's were clear. Her biggest complaint with the CPT11 was the fatigue and how long she had sit around while getting the infusion. She didn't suffer any of the other known side effects, but did develope an allergic reaction to the Avasitn. That was easily controlled by administering benedryll during the chemo. My mom was diagnosed in August of '05, and the Avastin/CPT11 coctail has kept her in the game today. Good luck!