I'm so sorry to hear of the suffering of your wife. I don't know where you live but would suggest that you take her to M D Anderson Cancer Center in Houston, TX for treatment. My sister also has metastatic melanoma in her lymph nodes (groin/breast/armpit) and got bio-chemo therapy there and she is in complete remission. The groin tumor has shrunk completely and the others are gone. If you would like to contact my sister for further information, I will give you her e-mail address.
Don't give up yet.
Narn