My dad was on the nexavar for three months. The blisters will subside after approx. 4 weeks. It helped my dad prolong his life and kept the cancer at bay. They took him off to try the SIRT radiation. Don't let them talk you into that. In the end it killed my father because the radiation killed his healthy liver. stick with the Nexavar. It is uncomfortable but will get better in time. we used to put diaper rash cream on his blisters and kept the hands and feet moist at all times. Good luck.