The dosage is wrong for sure. My surgeon had me taking 2 (25's) in the morning, but when I went to my first post-surgery appointment with my Endo, she said specifically not to take it like that. I believe she said that it's effectiveness is first felt within 2.5 hours and then starts tapering off at about 6. She instructed me to take 2 pills and split them in half and take it 4 times a day. I haven't had any side effects since.